Article
Expression of p53 protein in T- and natural killer-cell lymphomas is associated with some clinicopathologic entities but rarely related to p53 mutations.
Human pathology - 1 Feb 2001
Petit B, Leroy K, Kanavaros P, Boulland M L, Druet-Cabanac M, Haioun C, Bordessoule D, Gaulard P
Abstract excerpt
To determine if p53 abnormalities could be involved in the pathogenesis of T- or natural killer (NK)-cell lymphomas, we investigated 51 cases of these lymphomas for the expression of p53 and its relationship with p53 gene mutations, the expression of the p21 protein as well as the proliferative and apoptotic indices. Overexpression of p53 was found in 19 cases (37%), whereas mutations of the p53 gene were...
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