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Article

The pattern of p53 and p21WAF1/CIP1 immunoreactivity in non-Hodgkin's lymphomas predicts p53 gene status.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Aug 1997

Mansukhani M M, Osborne B M, Zhong J, Matsushima A Y

Abstract excerpt

P53 and p21WAF1/CIP1 (p21) immunostaining was performed on 92 non-Hodgkin's lymphomas (NHLs), and the staining pattern correlated with the presence or absence of p53 hot spot mutations as detected by PCR-SSCP of exons 5-8 and direct sequencing. Twenty-nine of 92 lymphomas overexpressed p53, and 1...

Topics

Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA, Neoplasm
Genes, p53
Humans
Immunohistochemistry
Lymphoma, Non-Hodgkin
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Sequence Analysis, DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

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Identifiers

PMID: 9360843
DOI: 10.1097/00019606-199708000-00006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9360843-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The pattern of p53 and p21WAF1/CIP1 immunoreactivity in non-Hodgkin's lymphomas predicts p53 gene status.PMID 9360843Read ↗

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p21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: a potential marker of p53 tumor-suppressor gene function.Semantic proximity Read ↗

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