Article
The expression of p53 protein in non-Hodgkin's lymphomas is not always dependent on p53 gene mutations.
Blood - 15 Nov 1993
Villuendas R, Piris M A, Algara P, Sánchez-Beato M, Sánchez-Verde L, Martinez J C, Orradre J L, García P, Lopez C, Martinez P
Abstract excerpt
p53 overexpression has been found to be a fairly common feature in high grade lymphomas in the majority of tumoral cells. The results vary from series to series, from 25% to 33% of cases. To assess whether immunohistochemical positivity for p53 correlated with the presence of structural gene abnormalities, DNA from 16 non-Hodgkin's lymphomas with high and low p53 values was amplified and sequenced to determine...
Topics
- Base Sequence
- Gene Expression
- Genes, p53
- Humans
- Immunohistochemistry
- Ki-67 Antigen
- Lymphoma, Non-Hodgkin
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Nuclear Proteins