Article
Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenetic mechanisms.
The Journal of pathology - 1 Jan 1997
Pilotti S, Della Torre G, Lavarino C, Di Palma S, Sozzi G, Minoletti F, Rao S, Pasquini G, Azzarelli A, Rilke F, Pierotti M A
Abstract excerpt
Recent findings have indicated that TP53 inactivation in sarcomas may result from mutation and/or deletion of the TP53 gene or, alternatively, from binding to the MDM2 gene products. To investigate further a possible role of the two genes in sarcomas, 24 large and deep-seated lipomas and 74 lipos...
Topics
- Adolescent
- Adult
- Aged
- Chromosome Aberrations
- Female
- Gene Expression
- Genotype
- Humans
- Immunoenzyme Techniques
- Immunophenotyping
- Lipoma
- Liposarcoma
- Male
- Middle Aged
- Neoplasm Proteins
- Nuclear Proteins