Article
Limited role of TP53 and TP53-related genes in myxoid liposarcoma.
Tumori - 1 Jan 2000
Pilotti S, Lavarino C, Mezzelani A, Della Torre C, Minoletti F, Sozzi G, Azzarelli A, Rilke F, Pierotti M A
Abstract excerpt
AIMS: Circumstantial evidence suggests that genetic changes may lead to tumor progression within the myxoid liposarcoma tumors (MLTs) carrying non-random chromosomal translocation t(12;16). METHODS: To address this subject an immunophenotypic analysis, applying antibodies against proteins encoded by TP53, MDM2 and CDK4 genes, complemented by molecular analysis of eight suitable cases, was performed on 104...
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