Article
Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma.
The Journal of pathology - 1 Jan 1997
Dei Tos A P, Doglioni C, Piccinin S, Maestro R, Mentzel T, Barbareschi M, Boiocchi M, Fletcher C D
Abstract excerpt
Dedifferentiated liposarcoma represents a distinct subtype of liposarcoma and is characterized by the presence of abrupt transition from well-differentiated liposarcoma to high-grade pleomorphic sarcoma (mostly MFH-like). A key role for p53 in tumour progression of this subset of liposarcomas has...
Topics
- Cell Differentiation
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Disease Progression
- Genes, p53
- Humans
- Immunoenzyme Techniques
- Liposarcoma
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- Tumor Suppressor Protein p53