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Article

Clinical and Biological Significance of <i>CDK4</i> Amplification in Well-Differentiated and Dedifferentiated Liposarcomas

9 Sept 2009

Abstract excerpt

PURPOSE: The MDM2 and HMGA2 genes are consistently amplified in well-differentiated/dedifferentiated liposarcomas (WDLPS/DDLPS) whereas CDK4 is frequently but not always amplified in these tumors. Our goal was to determine whether the absence of CDK4 amplification was (a) correlated to a specific clinico-histopathologic profile; and (b) compensated by another genomic anomaly involving the...

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PMID: 19737942
DOI: 10.1158/1078-0432.ccr-08-3185

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