Article
Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis.
Cancer - 15 Mar 1997
Ward R L, Todd A V, Santiago F, O'Connor T, Hawkins N J
Abstract excerpt
BACKGROUND: Recent in vitro data indicate that the oncogenic effects of activated ras genes may be mediated, at least in part, through inhibition of apoptotic cell death. To examine this proposition in vivo, the relationship between mutations of the K-ras gene and the frequency of apoptosis was studied in a series of 69 sporadic colorectal neoplasms (11 adenomas and 58 carcinomas). METHODS: Mutations in codon 12...
Topics
- Adenoma
- Adult
- Aged
- Aged, 80 and over
- Apoptosis
- Carcinoma
- Colorectal Neoplasms
- Female
- Gene Expression Regulation, Neoplastic
- Genes, bcl-2
- Genes, ras
- Humans