Article
Programmed cell death in colorectal carcinogenesis.
Anticancer research - 1 Jan 2000
Valentini A M, Caruso M L, Armentano R, Pirrelli M, Rizzi E, Lapenna F, Renna L
Abstract excerpt
The most studied mechanism of malignant transformation has been cell proliferation. The relationship between programmed cell death (apoptosis), cell proliferation, and apoptosis regulatory genes (p53 and bcl-2), was studied in normal colonic epithelium, 26 sporadic adenomas both early and late, 25 FAP adenomas, and 34 carcinomas. We showed a decrease in programmed cell death and an increase in cell proliferation...
Topics
- Apoptosis
- Colorectal Neoplasms
- Humans
- Immunohistochemistry
- Mutation
- Proliferating Cell Nuclear Antigen
- Proto-Oncogene Proteins c-bcl-2
- Tumor Suppressor Protein p53