Article
Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997
Fazeli A, Steen R G, Dickinson S L, Bautista D, Dietrich W F, Bronson R T, Bresalier R S, Lander E S, Costa J, Weinberg R A
Abstract excerpt
We have examined the effects of inactivation of the p53 tumor suppressor gene on the incidence of apoptotic cell death in two stages of the adenoma-to-carcinoma progression in the intestine: in early adenomas where p53 mutations are rare and in highly dysplastic adenomas where loss of p53 occurs frequently. Homozygosity for an inactivating germ-line mutation of p53 had no effect on the incidence or the rate of...
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