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Article

KRAS gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis.

American journal of clinical pathology - 1 Feb 2011

Liu Xiuli, Jakubowski Maureen, Hunt Jennifer L

Abstract excerpt

KRAS mutation occurs in 30% to 50% of colorectal cancers (CRCs) and has been suggested to be associated with proliferation and decreased apoptosis. In this study, we analyzed KRAS in 198 CRCs and compared the clinicopathologic variables between KRAS-mutated and wild-type CRCs. Also, a subset of 90 and 66 CRCs from this cohort underwent microsatellite instability testing and histomorphologic evaluation, and the...

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Source

Identifiers

PMID: 21228365
DOI: 10.1309/AJCP7FO2VAXIVSTP

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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