Article
Automated fluorescent detection of microsatellite instability.
Molecular biotechnology - 1 Mar 2001
Hirst G L, Illand M
Abstract excerpt
Microsatellites are highly polymorphic repetitive DNA segments dispersed throughout the genome and have been widely used for genetic linkage analysis and allele loss. Instability of microsatellites sequences has been linked to deficiencies in DNA mismatch repair, and is observed in a number of different tumor types. Analysis of microsatellite instability is thought to be a useful clinical tool for cancer...
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