Article
Microsatellite instability in colorectal cancer: improved assessment using fluorescent polymerase chain reaction.
Gastroenterology - 1 Aug 1995
Cawkwell L, Li D, Lewis F A, Martin I, Dixon M F, Quirke P
Abstract excerpt
BACKGROUND & AIMS: Microsatellite instability was first described in hereditary nonpolyposis colorectal cancers and sporadic colorectal cancers, in which it was associated with a good prognosis. The aim of this study was to assess the advantages of a novel fluorescent assay for detecting microsatellite instability. METHODS: Eleven fluorescently tagged microsatellites and an automated DNA sequencer were used to...
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