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Article

Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2012

Yaguchi Tomonori, Goto Yasufumi, Kido Kenji, Mochimaru Hiroshi, Sakurai Toshiharu, Tsukamoto Nobuo, Kudo-Saito Chie, Fujita Tomonobu, Sumimoto Hidetoshi, Kawakami Yutaka

Abstract excerpt

Cancer-induced immunosuppression is a major problem reducing antitumor effects of immunotherapies, but its molecular mechanism has not been well understood. We evaluated immunosuppressive roles of activated Wnt/β-catenin pathways in human melanoma for dendritic cells (DCs) and CTLs. IL-10 expression was associated with β-catenin accumulation in human melanoma cell lines and tissues and was induced by direct...

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Identifiers

PMID: 22815287
DOI: 10.4049/jimmunol.1102282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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