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Article

Integrated genomic profiling identifies loss of chromosome 11p impacting transcriptomic activity in aggressive pituitary PRL tumors.

Brain pathology (Zurich, Switzerland) - 1 Sept 2011

Wierinckx Anne, Roche Magali, Raverot Gérald, Legras-Lachuer Catherine, Croze Séverine, Nazaret Nicolas, Rey Catherine, Auger Carole, Jouanneau Emmanuel, Chanson Philippe, Trouillas Jacqueline, Lachuer Joël

Abstract excerpt

Integrative genomics approaches associating DNA structure and transcriptomic analysis should allow the identification of cascades of events relating to tumor aggressiveness. While different genome alterations have been identified in pituitary tumors, none have ever been correlated with the aggressiveness. This study focused on one subtype of pituitary tumor, the prolactin (PRL) pituitary tumors, to identify...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21251114
DOI: 10.1111/j.1750-3639.2011.00476.x
PMCID: PMC8094244

Genes

PRL
DGKZ
HTATIP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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