Article
Genome-wide loss of heterozygosity predicts aggressive, treatment-refractory behavior in pituitary neuroendocrine tumors.
Acta neuropathologica - 17 May 2024
Lin Andrew L, Rudneva Vasilisa A, Richards Allison L, Zhang Yanming, Woo Hyung Jun, Cohen Marc, Tisnado Jamie, Majd Nazanin, Wardlaw Sharon L, Page-Wilson Gabrielle, Sengupta Soma, Chow Frances, Goichot Bernard, Ozer Byram H, Dietrich Jorg, Nachtigall Lisa, Desai Arati, Alano Tina, Ogilive Shahiba, Solit David B, Bale Tejus A, Rosenblum Marc, Donoghue Mark T A, Geer Eliza B, Tabar Viviane
Abstract excerpt
Pituitary neuroendocrine tumors (PitNETs) exhibiting aggressive, treatment-refractory behavior are the rare subset that progress after surgery, conventional medical therapies, and an initial course of radiation and are characterized by unrelenting growth and/or metastatic dissemination. Two groups of patients with PitNETs were sequenced: a prospective group of patients (n = 66) who consented to sequencing prior...
Topics
- Humans
- Loss of Heterozygosity
- Pituitary Neoplasms
- Neuroendocrine Tumors
- Male
- Female
- Middle Aged
- Adult
- Aged