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Article

5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists.

European journal of clinical pharmacology - 1 Jun 2002

Fowler Stephen J, Hall Ian P, Wilson Andrew M, Wheatley Amanda P, Lipworth Brian J

Abstract excerpt

OBJECTIVE: To determine whether genetic polymorphisms of the core promoter region of the 5-lipoxygenase gene contribute to the clinical response to leukotriene receptor antagonists. METHODS: We retrospectively genotyped 52 asthmatics for mutations of this gene from four placebo-controlled studies measuring leukotriene receptor antagonist responses. All studies measured bronchodilator response, and bronchial...

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PMID: 12107604
DOI: 10.1007/s00228-002-0458-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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