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Article

New generation live vaccines against human respiratory syncytial virus designed by reverse genetics.

Proceedings of the American Thoracic Society - 1 Jan 2005

Collins Peter L, Murphy Brian R

Abstract excerpt

Development of a live pediatric vaccine against human respiratory syncytial virus (RSV) is complicated by the need to immunize young infants and the difficulty in balancing attenuation and immunogenicity. The ability to introduce desired mutations into infectious virus by reverse genetics provides a method for identifying and designing highly defined attenuating mutations. These can be introduced in combinations...

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Identifiers

PMID: 16113487
DOI: 10.1513/pats.200501-011AW
PMCID: PMC2713317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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