Sequence comparisons of A/AA/6/60 influenza viruses: mutations which may contribute to attenuation.

doi:10.1016/0168-1702(96)01292-0

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Article

Sequence comparisons of A/AA/6/60 influenza viruses: mutations which may contribute to attenuation.

Virus research - 1 Jun 1996

Herlocher M L, Clavo A C, Maassab H F

Abstract excerpt

Influenza virus infection is a worldwide public health threat. Cold-adaptation was used to develop a vaccine line (ca A/AA/6/60 H2N2) which promised to reduce the morbidity and mortality associated with influenza and to serve as a model for other live virus vaccines. This study establishes that t...

Topics

Animals
Databases, Factual
Humans
Influenza A virus
Mice
Mutation
Temperature
Viral Proteins
Virulence

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