Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage.

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Article

Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage.

The Journal of rheumatology - 1 Mar 1997

Lafeber F P, van Roy H L, van der Kraan P M, van den Berg W B, Bijlsma J W

Abstract excerpt

OBJECTIVE: One of the most prominent alterations that characterizes osteoarthritic cartilage damage is a reduction of proteoglycan content, reflecting an imbalance between synthesis and release of proteoglycans. Both synthesis and release depend on the activity of cartilage cells. Chondrocytes in...

Topics

Aged
Aged, 80 and over
Autoradiography
Cartilage
Cell Differentiation
Cells, Cultured
Female
Humans
Male
Osteoarthritis
Phenotype
Proteoglycans
Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 9058662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9058662-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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