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Article

Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage.

The Journal of rheumatology - 1 Mar 1997

Lafeber F P, van Roy H L, van der Kraan P M, van den Berg W B, Bijlsma J W

Abstract excerpt

OBJECTIVE: One of the most prominent alterations that characterizes osteoarthritic cartilage damage is a reduction of proteoglycan content, reflecting an imbalance between synthesis and release of proteoglycans. Both synthesis and release depend on the activity of cartilage cells. Chondrocytes in the upper layer of moderately osteoarthritic human knee cartilage appear to be phenotypically altered, including...

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PMID: 9058662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage.PMID 9058662Read ↗

Characterization of proteoglycans synthesized by rabbit articular chondrocytes in response to transforming growth factor-beta (TGF-beta).Semantic proximity Read ↗

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Activation of fibrillar collagen synthesis and phenotypic modulation of chondrocytes in early human osteoarthritic cartilage lesions.Semantic proximity Read ↗

Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage.Semantic proximity Read ↗

PTHrP overexpression partially inhibits a mechanical strain-induced arthritic phenotype in chondrocytes.Semantic proximity Read ↗

Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes.Semantic proximity Read ↗

Phenotypic modulation of newly synthesized proteoglycans in human cartilage and chondrocytes.Semantic proximity Read ↗

IL-40 is up-regulated in the synovial fluid and cartilage of osteoarthritis patients and contributes to the alteration of chondrocytes phenotype in vitro.Semantic proximity Read ↗

Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage.Semantic proximity Read ↗

Differential modulation of growth and phenotypic expression of chondrocytes in sparse and confluent cultures by growth factors in cartilage.Semantic proximity Read ↗

Alteration in the differentiated phenotypes of cultured chondrocytes from human articular cartilage under various culture conditions.Semantic proximity Read ↗

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