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Article

Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage.

Arthritis and rheumatism - 1 Jul 1999

Aigner T, Zhu Y, Chansky H H, Matsen F A, Maloney W J, Sandell L J

Abstract excerpt

OBJECTIVE: To test for the reexpression of the chondroprogenitor splice variant of the gene COL2A1, type IIA procollagen (containing a cysteine-rich NH2 propeptide), in adult articular chondrocytes in osteoarthritic (OA) joint disease. METHODS: In situ hybridization and immunohistochemical localization were performed on normal and OA articular cartilage specimens. The presence of type IIA procollagen messenger...

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Identifiers

PMID: 10403272
DOI: 10.1002/1529-0131(199907)42:7<1443::AID-ANR18>3.0.CO;2-A

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