Activation of fibrillar collagen synthesis and phenotypic modulation of chondrocytes in early human osteoarthritic cartilage lesions.

doi:10.1016/s1063-4584(97)80013-1

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Article

Activation of fibrillar collagen synthesis and phenotypic modulation of chondrocytes in early human osteoarthritic cartilage lesions.

Osteoarthritis and cartilage - 1 May 1997

Aigner T, Glückert K, von der Mark K

Abstract excerpt

The objective of this study was to investigate the expression and extracellular distribution of fibrillar collagen types I, II, and III in early stage osteoarthritic cartilage in order to elucidate matrix gene expression and cell differentiation in early phases of the disease. Arthroscopically, d...

Topics

Adult
Cartilage
Cell Differentiation
Cells, Cultured
Collagen
Gene Expression
Histocytochemistry
Humans
In Situ Hybridization
Knee Joint
Middle Aged
Osteoarthritis
Phenotype
RNA Probes
RNA, Messenger

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