Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-40 is up-regulated in the synovial fluid and cartilage of osteoarthritis patients and contributes to the alteration of chondrocytes phenotype in vitro.

Arthritis research & therapy - 30 Jul 2024

Cerezo L Andrés, Navrátilová A, Kuklová M, Prokopcová A, Baloun J, Kropáčková T, Veigl D, Popelka S, Fulín P, Ballay R, Pavelka K, Vencovský J, Šenolt L

Abstract excerpt

INTRODUCTION: IL-40 is a novel cytokine associated with autoimmune connective tissue disorders such as rheumatoid arthritis (RA) or Sjögren syndrome. We have previously shown an accumulation of IL-40 in the RA joint and its expression by immune cells and fibroblasts. Therefore, we aimed to assess the role of IL-40 in association with hyaline cartilage and chondrocyte activity. METHODS: Immunohistochemistry was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage, Articular
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Immunohistochemistry

Share to Interleukins

Share to Osteoarthritis

Share to Synovial Fluid

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 39080724
DOI: 10.1186/s13075-024-03372-z
PMCID: PMC11289996

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-40 is up-regulated in the synovial fluid and cartilage of osteoarthritis patients and contributes to the alteration of chondrocytes phenotype in vitro.PMID 39080724Read ↗

Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitrostudySemantic proximity Read ↗

Clinical Significance of Inflammatory Factors Within the Synovial Fluids in Patients With Knee Osteoarthritis for Predicting Meniscus Degeneration ProgressionSemantic proximity Read ↗

Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis.Semantic proximity Read ↗

Direct comparison of non-osteoarthritic and osteoarthritic synovial fluid-induced intracellular chondrocyte signaling and phenotype changes.Semantic proximity Read ↗

IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathologySemantic proximity Read ↗

An ex vivo tissue model of cartilage degradation suggests that cartilage state can be determined from secreted key protein patternsSemantic proximity Read ↗

Carrageenan-induced transient inflammation in a rabbit knee model: molecular changes consistent with an early osteoarthritis phenotype.Semantic proximity Read ↗

Pro-inflammatory effects of human apatite crystals extracted from patients suffering from calcific tendinopathy.Semantic proximity Read ↗

Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage.Semantic proximity Read ↗

Human cartilage gp-39+,CD16+ monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis.Semantic proximity Read ↗

Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis.Semantic proximity Read ↗

Cathepsin g degrades synovial fluid lubricin: relevance for osteoarthritis pathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.