Article
Cloning of canine cytochrome P450 2E1 cDNA: identification and characterization of two variant alleles.
Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2000
Lankford S M, Bai S A, Goldstein J A
Abstract excerpt
Cytochrome P450 (CYP) 2E1 is a toxicologically important enzyme that inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. Although cDNAs for the human, rodent, and rabbit forms of CYP2E1 have been isolated and studied extensively, there is an absence of information about canine CYP2E1, despite the fact that the dog is routinely...
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