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Article

The induction of forward and reverse specific-locus mutations and dominant cataract mutations in spermatogonia of treated strain DBA/2 mice by ethylnitrosourea.

Mutation research - 1 Aug 1991

Favor J, Neuhäuser-Klaus A, Ehling U H

Abstract excerpt

The mutagenic effectiveness of ethylnitrosurea (ENU) was assessed in treated spermatogonia of DBA/2 mice. In a total of 17,515 offspring examined following 160 mg ENU/kg body weight treatment of parental males, 26 forward specific-locus mutations, 2 reverse specific-locus mutations and 9 dominant cataract mutations were recovered. ENU increased the mutation rate to all 3 genetic endpoints. However, ENU was less...

Topics

Alleles
Animals
Base Composition
Cataract
DNA Repair
Ethylnitrosourea
Genes, Dominant
Genes, Lethal
Injections, Intraperitoneal
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred DBA

Mutagenesis

Spermatogonia

Source

Identifiers

PMID: 2072972
DOI: 10.1016/0027-5107(91)90003-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2072972-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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