Article
Identification of trans-acting genes necessary for centromere function in Drosophila melanogaster using centromere-defective minichromosomes.
Genetics - 1 Mar 1997
Cook K R, Murphy T D, Nguyen T C, Karpen G H
Abstract excerpt
Deletions in the Drosophila minichromosome Dp1187 were used to investigate the genetic interactions of trans-acting genes with the centromere. Mutations in several genes known to have a role in chromosome inheritance were shown to have dominant effects on the stability of minichromosomes with partially defective centromeres. Heterozygous mutations in the ncd and klp3A kinesin-like protein genes strongly reduced...
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