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Article

Parallel pathways for recruiting effector proteins determine centromere drive and suppression.

Cell - 16 Sept 2021

Kumon Tomohiro, Ma Jun, Akins R Brian, Stefanik Derek, Nordgren C Erik, Kim Junhyong, Levine Mia T, Lampson Michael A

Abstract excerpt

Selfish centromere DNA sequences bias their transmission to the egg in female meiosis. Evolutionary theory suggests that centromere proteins evolve to suppress costs of this "centromere drive." In hybrid mouse models with genetically different maternal and paternal centromeres, selfish centromere DNA exploits a kinetochore pathway to recruit microtubule-destabilizing proteins that act as drive effectors. We show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34433012
DOI: 10.1016/j.cell.2021.07.037
PMCID: PMC8448984

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