Article
Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos.
Development (Cambridge, England) - 1 Jan 1997
Duncan S A, Nagy A, Chan W
Abstract excerpt
Immediately prior to gastrulation the murine embryo consists of an outer layer of visceral endoderm (VE) and an inner layer of ectoderm. Differentiation and migration of the ectoderm then occurs to produce the three germ layers (ectoderm, embryonic endoderm and mesoderm) from which the fetus is d...
Topics
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Endoderm
- Gastrula
- Gene Expression Regulation, Developmental
- Genotype
- Hepatocyte Nuclear Factor 4
- In Situ Hybridization
- Mice
- Mice, Knockout
- Phosphoproteins
- Polymerase Chain Reaction
- Polyploidy
- RNA, Messenger
- Stem Cells
- Transcription Factors