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Article

GATA4 is essential for formation of the proepicardium and regulates cardiogenesis

13 Aug 2004

Abstract excerpt

The role of GATA4 during the earliest stages of cardiogenesis has not been defined because Gata4 knockout embryos suffer an early developmental arrest caused by deficiencies in extraembryonic visceral endoderm function. We have used tetraploid embryo complementation to rescue these defects and generated clonal embryonic day 9.5 Gata4(-/-) embryos directly from embryonic stem cells. GATA4-null embryos display...

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PMID: 15310850
DOI: 10.1073/pnas.0400752101

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