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Article

RAG s and R egulation of A utoantibodies

19 Mar 2004

Abstract excerpt

Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and...

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PMID: 15032586
DOI: 10.1146/annurev.immunol.22.012703.104707

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