Article
p53-deficient mice are protected against adrenalectomy-induced apoptosis.
Neuroreport - 20 Dec 1996
Sakhi S, Gilmore W, Tran N D, Schreiber S S
Abstract excerpt
The p53 tumor suppressor gene, an important regulator of the cell cycle, has been implicated in apoptotic cell death in vitro, and more recently in neuronal degeneration in vivo. The present study investigated the importance of p53 expression in the apoptotic death of hippocampal granule cells following adrenalectomy. Mice, either homozygous or heterozygous for the p53 null allele and wild-type controls were...
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