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Article

Antigenic escape selects for the evolution of higher pathogen transmission and virulence.

Nature ecology & evolution - 1 Jan 2022

Sasaki Akira, Lion Sébastien, Boots Mike

Abstract excerpt

Despite the propensity for complex and non-equilibrium dynamics in nature, eco-evolutionary analytical theory typically assumes that populations are at equilibria. In particular, pathogens often show antigenic escape from host immune defences, leading to repeated epidemics, fluctuating selection and diversification, but we do not understand how this impacts the evolution of virulence. We model the impact of...

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Identifiers

PMID: 34949816
DOI: 10.1038/s41559-021-01603-z
PMCID: PMC9671278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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