Article
Inward rectification in ClC-0 chloride channels caused by mutations in several protein regions.
The Journal of general physiology - 1 Aug 1997
Ludewig U, Jentsch T J, Pusch M
Abstract excerpt
Several cloned ClC-type Cl- channels open and close in a voltage-dependent manner. The Torpedo electric organ Cl- channel, ClC-0, is the best studied member of this gene family. ClC-0 is gated by a fast and a slow gating mechanism of opposite voltage direction. Fast gating is dependent on voltage and on the external and internal Cl- concentration, and it has been proposed that the permeant anion serves as the...
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