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Article

Two physically distinct pores in the dimeric ClC-0 chloride channel.

Nature - 26 Sept 1996

Ludewig U, Pusch M, Jentsch T J

Abstract excerpt

The Torpedo chloride channel ClC-0 is the prototype of a large family of chloride channels that have roles in transepithelial transport and in regulating electrical excitability and cell volume. ClC-0 opens in bursts with two identical conductance levels of approximately 8pS. Hyperpolarization slowly increases the probability of bursts ('slow gating'), and depolarization increases channel opening within bursts...

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Identifiers

PMID: 8848047
DOI: 10.1038/383340a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two physically distinct pores in the dimeric ClC-0 chloride channel.PMID 8848047Read ↗

Determinants of slow gating in ClC-0, the voltage-gated chloride channel of Torpedo marmorata.Semantic proximity Read ↗

Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0.Semantic proximity Read ↗

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.Semantic proximity Read ↗

Proton sensing of CLC-0 mutant E166D.Semantic proximity Read ↗

The voltage-dependent ClC-2 chloride channel has a dual gating mechanism.Semantic proximity Read ↗

Temperature dependence of fast and slow gating relaxations of ClC-0 chloride channels.Semantic proximity Read ↗

Structure and function of ClC chloride channels.Semantic proximity Read ↗

Intracellular proton regulation of ClC-0.Semantic proximity Read ↗

Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain.Semantic proximity Read ↗

Chloride dependence of hyperpolarization-activated chloride channel gates.Semantic proximity Read ↗

The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0.Semantic proximity Read ↗

Insights into CLC-0's Slow-Gating from Intracellular Proton Inhibition.Semantic proximity Read ↗

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