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Article

Drastic reduction of the slow gate of human muscle chloride channel (ClC-1) by mutation C277S.

The Journal of physiology - 1 Aug 2001

Accardi A, Ferrera L, Pusch M

Abstract excerpt

1. Single channel measurements suggest that the human muscle chloride channel ClC-1 presumably has a double barrelled structure, with a fast single protopore gate and a slow common pore gate similar to that of ClC-0, the chloride channel from Torpedo. The single point mutation C212S has been shown to abolish the slow gating of ClC-0 locking the slow gate in the open state. In order to test the hypothesis that the...

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Identifiers

PMID: 11483705
DOI: 10.1111/j.1469-7793.2001.00745.x
PMCID: PMC2278749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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