Article
The nature of diversity of HLA-DRB1 exon 3.
Tissue antigens - 1 Oct 2007
Horn P A, Albis-Camps M, Verboom M, Bunce M, Yousaf K, Williams S, Blasczyk R
Abstract excerpt
Exon 3 of DRB1 is known to be polymorphic, but thought to be conserved within allelic groups. This implies that exon 3 polymorphisms would not need to be considered in evolutionary studies or clinical settings when assessing immunogenicity of allelic mismatches in stem cell transplantation. To further assess this, we determined the sequences of DRB1 exon 3 by hemizygote amplification and direct sequencing on 55...
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