Article
Mutations in the carboxyl terminus of the agouti protein decrease agouti inhibition of ligand binding to the melanocortin receptors.
Biochemistry - 25 Feb 1997
Kiefer L L, Ittoop O R, Bunce K, Truesdale A T, Willard D H, Nichols J S, Blanchard S G, Mountjoy K, Chen W J, Wilkison W O
Abstract excerpt
Several mutations that cause ectopic expression of the agouti gene result in obesity, hyperinsulinemia, and yellow coat color. A candidate pathway for agouti induced obesity and hyperinsulinemia is through altered signaling by melanocortin receptors, as agouti normally regulates coat coloration t...
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