Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Agouti regulates adipocyte transcription factors.

American journal of physiology. Cell physiology - 1 Apr 2001

Mynatt R L, Stephens J M

Abstract excerpt

Agouti is a secreted paracrine factor that regulates pigmentation in hair follicle melanocytes. Several dominant mutations cause ectopic expression of agouti, resulting in a phenotype characterized by yellow fur, adult-onset obesity and diabetes, increased linear growth and skeletal mass, and increased susceptibility to tumors. Humans also produce agouti protein, but the highest levels of agouti in humans are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Adipocytes
Share to Agouti Signaling Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to alpha-MSH

Share to Leptin

Share to Receptors, Cytoplasmic and Nuclear

Share to STAT1 Transcription Factor

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 11245612
DOI: 10.1152/ajpcell.2001.280.4.C954

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Agouti regulates adipocyte transcription factors.PMID 11245612Read ↗

Agouti Expression in Human Adipose TissueSemantic proximity Read ↗

The yellow mouse obesity syndrome and mechanisms of agouti-induced obesity.Semantic proximity Read ↗

An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice.Semantic proximity Read ↗

Agouti/melanocortin interactions with leptin pathways in obesity.Semantic proximity Read ↗

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related ProteinSemantic proximity Read ↗

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.Semantic proximity Read ↗

The role of the Agouti-Related Protein in energy balance regulation.Semantic proximity Read ↗

Structure and function of <i>ASP</i>, the human homolog of the mouse <i>agouti</i> geneSemantic proximity Read ↗

The agouti gene: turned on to yellow.Semantic proximity Read ↗

A novel human monogenic obesity trait: severe early-onset childhood obesity caused by aberrant expression of agouti-signaling protein (ASIP): a case reportSemantic proximity Read ↗

Overexpression of an Agouti cDNA in the skin of transgenic mice recapitulates dominant coat color phenotypes of spontaneous mutants.Semantic proximity Read ↗

A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.