Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.

Biochemical and biophysical research communications - 2 Jan 2015

Yun Ji-Hye, Kim Kuglae, Jung Youngjin, Park Jae-Hyun, Cho Hyun-Soo, Lee Weontae

Abstract excerpt

G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melanocortin-4 receptor (hMC4R) plays an important role in the control of energy homeostasis, and its mutants are directly related to severe human obesity. Here, we describe optimized protocols for the high-yield...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agouti-Related Protein
Share to Bacteriophage T4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography

Share to Chromatography, Gel

Share to Insecta

Share to Muramidase

Share to Receptor, Melanocortin, Type 4

Share to Solubility

Source

Identifiers

PMID: 25446108
DOI: 10.1016/j.bbrc.2014.11.044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.PMID 25446108Read ↗

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.Semantic proximity Read ↗

Structural determinants regulating cell surface targeting of melanocortin receptors.Semantic proximity Read ↗

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients.Semantic proximity Read ↗

Chimeras of the agouti-related protein: insights into agonist and antagonist selectivity of melanocortin receptors.Semantic proximity Read ↗

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related ProteinSemantic proximity Read ↗

A polymorphism in the human agouti-related protein is associated with late-onset obesity.Semantic proximity Read ↗

Pharmacological chaperones for the misfolded melanocortin-4 receptor associated with human obesity.Semantic proximity Read ↗

Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors.Semantic proximity Read ↗

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists.Semantic proximity Read ↗

Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.Semantic proximity Read ↗

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.Semantic proximity Read ↗

Attractin-Like Protein 1 (ATRNL1): An Essential Partner of MC4R to Regulate Body WeightSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.