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Article

Mature and progenitor endothelial cells perform angiogenesis also under protease inhibition: the amoeboid angiogenesis.

Journal of experimental & clinical cancer research : CR - 3 Apr 2018

Chillà Anastasia, Margheri Francesca, Biagioni Alessio, Del Rosso Mario, Fibbi Gabriella, Laurenzana Anna

Abstract excerpt

BACKGROUND: Controlling vascular growth is a challenging aim for the inhibition of tumor growth and metastasis. The amoeboid and mesenchymal types of invasiveness are two modes of migration interchangeable in cancer cells: the Rac-dependent mesenchymal migration requires the activity of proteases; the Rho-ROCK-dependent amoeboid motility is protease-independent and has never been described in endothelial cells....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Neovascularization, Pathologic

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Share to rac1 GTP-Binding Protein

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Share to Urokinase-Type Plasminogen Activator

Source

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Identifiers

PMID: 29615071
DOI: 10.1186/s13046-018-0742-2
PMCID: PMC5883600

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