Article
AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.
Molecular and cellular biology - 1 Feb 2006
Spence Heather J, McGarry Lynn, Chew Catherine S, Carragher Neil O, Scott-Carragher Linda A, Yuan Zhengqiang, Croft Daniel R, Olson Michael F, Frame Margaret, Ozanne Bradford W
Abstract excerpt
The transcription factor AP-1, which is composed of Fos and Jun family proteins, plays an essential role in tumor cell invasion by altering gene expression. We report here that Krp1, the AP-1 up-regulated protein that has a role in pseudopodial elongation in v-Fos-transformed rat fibroblast cells, forms a novel interaction with the nondifferentially expressed actin binding protein Lasp-1. Krp1 and Lasp-1...
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