Article
Mechanism of Ca2+ and monosaccharide binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor.
The Journal of biological chemistry - 28 Feb 1997
Mullin N P, Hitchen P G, Taylor M E
Abstract excerpt
Site-directed mutagenesis has been used to identify residues that ligate Ca2+ and sugar to the fourth C-type carbohydrate-recognition domain (CRD) of the macrophage mannose receptor. CRD-4 is the only one of the eight CRDs of the mannose receptor to exhibit detectable monosaccharide binding when...
Topics
- Alanine
- Animals
- Asparagine
- Aspartic Acid
- Binding Sites
- Calcium
- Kinetics
- Lectins
- Lectins, C-Type
- Macrophages
- Magnetic Resonance Spectroscopy
- Mannose Receptor
- Mannose-Binding Lectins
- Mice
- Models, Molecular
- Monosaccharides
- Mutagenesis, Site-Directed
- Phenotype