Article
Development of a specific system for targeting protein to metallophilic macrophages.
Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2004
Taylor Philip R, Zamze Susanne, Stillion Richard J, Wong Simon Y C, Gordon Siamon, Martinez-Pomares Luisa
Abstract excerpt
The cysteine-rich domain (CR) of the mannose receptor binds sulfated glycoprotein CR ligand (CRL) expressed by subpopulations of myeloid cells in secondary lymphoid organs (CRL(+) cells). In naïve mice, these CRL(+) cells, metallophilic macrophages (M) in spleen and subcapsular sinus M in lymph nodes, are located strategically for antigen capture and are adjacent to B cell follicles, but their role in the immune...
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