Article
Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.
Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013
Furukawa Atsushi, Kamishikiryo Jun, Mori Daiki, Toyonaga Kenji, Okabe Yuki, Toji Aya, Kanda Ryo, Miyake Yasunobu, Ose Toyoyuki, Yamasaki Sho, Maenaka Katsumi
Abstract excerpt
Mincle [macrophage inducible Ca(2+)-dependent (C-type) lectin; CLEC4E] and MCL (macrophage C-type lectin; CLEC4D) are receptors for the cord factor TDM (trehalose-6,6'-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activate immune cells to confer adjuvant activity. Although it is known that receptor-TDM interactions require both sugar and lipid moieties of TDM, the mechanisms of...
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