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Article

Scleroderma fibroblasts show increased responsiveness to endothelial cell-derived IL-1 and bFGF.

The Journal of investigative dermatology - 1 Mar 1997

Denton C P, Xu S, Black C M, Pearson J D

Abstract excerpt

Fibroblasts cultured from lesional skin in scleroderma (systemic sclerosis) demonstrate an activated phenotype that may be important in pathogenesis. Endothelial cell-derived cytokines can modulate fibroblast properties, and endothelial cell changes occur early in scleroderma. Thus, endothelial cell and fibroblast dysfunction may be linked through the paracrine activity of soluble endothelial cell products. We...

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Identifiers

PMID: 9036923
DOI: 10.1111/1523-1747.ep12286455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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