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Article

Novel functions of intracellular IL-1ra in human dermal fibroblasts: implications in the pathogenesis of fibrosis.

The Journal of investigative dermatology - 1 Apr 2006

Kanangat Siva, Postlethwaite Arnold E, Higgins Gloria C, Hasty Karen A

Abstract excerpt

Intracellular IL-1 receptor antagonist (icIL-1ra) is reportedly involved in functions independent of blocking IL-1 receptor signaling. Fibroblasts derived from the involved skin of patients with systemic sclerosis (SSc) are predominantly of the myofibroblast phenotype, with higher levels of icIL-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16456536
DOI: 10.1038/sj.jid.5700097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16456536-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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