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Article

Recent advances in fibroblast signaling and biology in scleroderma

19 Oct 2004

Abstract excerpt

PURPOSE OF REVIEW: Systemic sclerosis is a complex disease manifesting itself by fibrosis of skin and other internal organs. Fibroblasts isolated from scleroderma lesions and cultured in vitro are characterized by increased synthesis of collagen and other extracellular matrix proteins, consistent with the disease phenotype. Cultured systemic sclerosis fibroblasts therefore serve as a principal experimental model...

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Identifiers

PMID: 15577613
DOI: 10.1097/01.bor.0000137894.63091.1a

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Source receipt: pubmed, retrieved 7 Sept 2026.

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