Article
Changes in CD11b and L-selectin expression on eosinophils are mediated by human lung fibroblasts in vitro.
American journal of respiratory and critical care medicine - 1 Sept 1998
Spoelstra F M, Hovenga H, Noordhoek J A, Postma D S, Kauffman H F
Abstract excerpt
Eosinophilic airway infiltration is a central feature in asthma. Eosinophils recovered from bronchoalveolar fluid show an activated phenotype, e.g., increased CD11b and decreased L-selectin expression. We investigated whether lung fibroblasts are able to activate eosinophils in vitro, and if so,...
Topics
- Adolescent
- Adult
- Antibodies
- Asthma
- Bronchoalveolar Lavage Fluid
- Cell Communication
- Cell Survival
- Cells, Cultured
- Culture Media, Conditioned
- Eosinophils
- Fibroblasts
- Flow Cytometry
- Gene Expression Regulation
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Interleukin-1
- L-Selectin
- Lung