Article
Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2013
Myles-Worsley Marina, Tiobech Josepha, Browning Sharon R, Korn Jeremy, Goodman Sarah, Gentile Karen, Melhem Nadine, Byerley William, Faraone Stephen V, Middleton Frank A
Abstract excerpt
Growing evidence for genetic overlap between schizophrenia (SCZ) and bipolar disorder (BPD) suggests that causal variants of large effect on disease risk may cross traditional diagnostic boundaries. Extended multigenerational families with both SCZ and BPD cases can be a valuable resource for discovery of shared biological pathways because they can reveal the natural evolution of the underlying genetic...
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