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Article

Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung.

Carcinogenesis - 1 May 2008

Licchesi Julien D F, Westra William H, Hooker Craig M, Machida Emi O, Baylin Stephen B, Herman James G

Abstract excerpt

BACKGROUND: Atypical adenomatous hyperplasia (AAH) is now recognized as a precursor lesion from which lung adenocarcinomas arise and thus represents an ideal target for studying the early genetic and epigenetic alterations associated with lung tumorigenesis such as alterations of the Wnt pathway. METHODS: We assessed the level of Wnt signaling activity in lung cancer cell lines by determining the level of active...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Glandular and Epithelial

Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 18308762
DOI: 10.1093/carcin/bgn017
PMCID: PMC3312609

Genes

APC
DKK1
DKK3
RUNX3
SFRP1
WIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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